|1st appearance:||It Happening One Night|
|Voice Artist:||Chris McCulloch|
Wes Warhammer is an avant-garde super-villain and the leader of a legion of villains called The Doom Factory. He is a Level 10 antagonist based in New York City.
Wes Warhammer was a member of Wide Wale's Fiends and Family Plan for arching Dr. Venture. Sometime after the deaths of Haranguetan and Think Tank, Wes was cleared for arching. Wes and the rest of the Doom Factory sent Dr. Venture a threatening video warning of his "Doom". The team infiltrated VenTech Tower and began to redecorate the Venture home to throw a chic party. Wes and Black Maria set up a film set in the panic room and distracted Dr. Venture using him as the subject for some experimental film-making. Wes slipped out and joined the rest of the party as the other members of The Doom Factory stole Dr. Venture's 'science stuff'.
Wes and the Doom Factory left the party behind, and a very confused Dr. Venture, in their large flying headquarters. Unbeknownst to them it had been rigged with explosives by the new Blue Morpho and Kano. Wes was apparently killed in the resulting explosion.
- Wes Warhammer is a parody mash-up of DC Comics villain Lex Luthor and pop artist Andy Warhol.